The Quality Control Scientist will lead the development and validation of analytical methods to provide complex analyses of biomolecules, especially DNA and RNA. The successful candidate will be responsible for providing expertise relating to analytical method validation and QC systems in general as they pertain to cGMP production of biologic therapeutics.  This position will also support internal manufacturing operations.

Responsibilities

• Optimize, qualify, and validate analytical methods for the quantitation and/or qualitative characterization of mRNA, plasmid DNA, proteins, and small molecules with limited supervision or guidance

• Maintain analytical methods in a state of validation that is fit for use

• Maintain stocks of critical reagents and supplies, including reference standard materials

• Develop and apply statistical methods as needed

• Document all work R&D in electronic lab notebook, QbD, or GMP system as appropriate.

• Provide reports for regulatory filings

• Perform or manage routine testing of raw materials, in-process intermediates, and finished products.

• Recognize, report, and investigate out-of-specification or unexpected results

• Mentor peers and junior level staff.

• Become an essential part of Vernal’s origin story

• Enjoy the benefits of living in Vermont

Requirements and Desirable skills

• Masters or Ph.D. degree in cell or molecular biology, biomedical or chemical engineering, biochemistry, or a related field

• Nucleic acid or protein chemistry: HPLC, UV/VIS spectrophotometry, PCR, qPCR, RT-qPCR, gel electrophoresis, interpretation and analysis of DNA sequencing and LC/MS

• Biochemistry: polyacrylamide gel electrophoresis (PAGE), western blotting, other forms of immunoblotting (e.g. dot and slot blots), silver staining, Bioanalyzer, DLS

• Method Optimization through design of experiments

• Deep understanding and practical knowledge of the scientific method and selection of experimental controls

• High attention to detail including planning, executing, and documenting experiments

• Communication skills including protocol writing, working directly with clients, Power Point

How to apply

Please email your resume and cover letter to careers@vernal.bio.